CHRNA4 CLIA Kit for Human(Homo sapiens) | EIAab.comCHRNA4 CLIA Kit for Human(Homo sapiens)

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Index > Protein center > CHRNA4(Gene name) > Human

CHRNA4 (Gene name),

Neuronal acetylcholine receptor subunit alpha-4 (Protein name ), ACHA4_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

CHRNA4(NACRA4);

Protein name:

Neuronal acetylcholine receptor subunit alpha-4;

Alternative:

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Neuronal AChR is composed of two different types of subunits: alpha and beta. Alpha-4 subunit can be combined to beta-2 or beta-4 to give rise to functional receptors. Interacts with RIC3; which is required for proper folding and assembly.

Function:

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

Subcellular Location:

Cell junction synapse postsynaptic cell membrane Multi-pass membrane protein Cell membrane Multi-pass membrane protein

Protein Attributes:

Sequence length:

627

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

627:

IFLWMFIIVC | LLGTVGLFLP | PWLAGMI

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

P43681

STRING:

9606.ENSP00000359285

String:

P43681

Pfam:

PF02931

MIM:

118504

UniGene:

Hs.10734

KEGG:

hsa:1137

Uniprot:

P43681

FOR

ELISA Kit for Human Neuronal acetylcholine receptor subunit alpha-4

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E1913m

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ELISA Kit for Human Neuronal acetylcholine receptor subunit alpha-4

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E1913c

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ELISA Kit for Human Neuronal acetylcholine receptor subunit alpha-4

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E1913h

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ELISA Kit for Human Neuronal acetylcholine receptor subunit alpha-4

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E1913r

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96T

CLIA Kit for Human Neuronal acetylcholine receptor subunit alpha-4

Cat.:

U1913m

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96T

CLIA Kit for Human Neuronal acetylcholine receptor subunit alpha-4

Cat.:

U1913h

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96T

CLIA Kit for Human Neuronal acetylcholine receptor subunit alpha-4

Cat.:

U1913c

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96T

CLIA Kit for Human Neuronal acetylcholine receptor subunit alpha-4

Cat.:

U1913r

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Polyclonal Antibody for Human Neuronal acetylcholine receptor subunit alpha-4

Cat.:

P1913Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human Neuronal acetylcholine receptor subunit alpha-4

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P1913Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human Neuronal acetylcholine receptor subunit alpha-4

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P1913Rb-h

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40ug/0.2ml

Monoclonal Antibody for Human Neuronal acetylcholine receptor subunit alpha-4

Protein for Human Neuronal acetylcholine receptor subunit alpha-4

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Cloning and transient expression of genes encoding the human alpha-4 and beta-2 neuronal nicotinic acetylcholine receptor (nAChR) subunits."
Monteggia L.M. , Gopalakrishnan M. , Touma E. , Idler K.B. , Nash N. , Arneric S.P. , Sullivan J.P. , Giordano T.
Gene155:189-193(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Brain.
2.

"Exon-intron structure of the human neuronal nicotinic acetylcholine receptor alpha 4 subunit (CHRNA4)."
Steinlein O.K. , Weiland S. , Stood J. , Propping P.
Genomics32:289-294(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
3.

"Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits."
Elliott K.J. , Ellis S.B. , Berckhan K.J. , Urrutia A. , Chavez-Noriega L.E. , Johnson E.C. , Velicelebi G. , Harpold M.M.
J. Mol. Neurosci.7:217-228(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Hippocampus.
4.

"Cloning and sequence of full-length cDNAs encoding the human neuronal nicotinic acetylcholine receptor (nAChR) subunits beta3 and beta4 and expression of seven nAChR subunits in the human neuroblastoma cell line SH-SY5Y and/or IMR-32."
Groot Kormelink P.J. , Luyten W.H.M.L.
FEBS Lett.400:309-314(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
5.

NIEHS SNPs program
Submitted (2005-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS GLY-387 AND LEU-517
6.

"The DNA sequence and comparative analysis of human chromosome 20."
Deloukas P. , Matthews L.H. , Ashurst J.L. , Burton J. , Gilbert J.G.R. , Jones M. , Stavrides G. , Almeida J.P. , Babbage A.K. , Bagguley C.L. , Bailey J. , Barlow K.F. , Bates K.N. , Beard L.M. , Beare D.M. , Beasley O.P. , Bird C.P. , Blakey S.E. , more...
Nature414:865-871(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
8.

"Molecular cloning of human neuronal nicotinic acetylcholine receptor 4-like subunit."
Mamalaki A. , Remoundos M. , Tzartos S.
Submitted (1995-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 26-627 (ISOFORM 1)
tissue: Brain.
9.

"RIC-3 enhances functional expression of multiple nicotinic acetylcholine receptor subtypes in mammalian cells."
Lansdell S.J. , Gee V.J. , Harkness P.C. , Doward A.I. , Baker E.R. , Gibb A.J. , Millar N.S.
Mol. Pharmacol.68:1431-1438(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RIC3
10.

"NMR structures of the transmembrane domains of the alpha4beta2 nAChR."
Bondarenko V. , Mowrey D. , Tillman T. , Cui T. , Liu L.T. , Xu Y. , Tang P.
Biochim. Biophys. Acta1818:1261-1268(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 242-625;SUBUNIT;FUNCTION
11.

"A missense mutation in the neuronal nicotinic acetylcholine receptor alpha-4 subunit is associated with autosomal dominant nocturnal frontal lobe epilepsy."
Steinlein O.K. , Mulley J.C. , Propping P. , Wallace R.H. , Phillips H.A. , Sutherland G.R. , Scheffer I.E. , Berkovic S.F.
Nat. Genet.11:201-203(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ENFL1 PHE-280
12.

"A novel mutation of CHRNA4 responsible for autosomal dominant nocturnal frontal lobe epilepsy."
Hirose S. , Iwata H. , Akiyoshi H. , Kobayashi K. , Ito M. , Wada K. , Kaneko S. , Mitsudome A.
Neurology53:1749-1753(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ENFL1 LEU-280
13.

"A Korean kindred with autosomal dominant nocturnal frontal lobe epilepsy and mental retardation."
Cho Y.-W. , Motamedi G.K. , Laufenberg I. , Sohn S.-I. , Lim J.-G. , Lee H. , Yi S.-D. , Lee J.-H. , Kim D.-K. , Reba R. , Gaillard W.D. , Theodore W.H. , Lesser R.P. , Steinlein O.K.
Arch. Neurol.60:1625-1632(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ENFL1 LEU-280

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